![]() One of the crucial elements of successful dental implant surgery is the effective osseointegration surrounding implants. ![]() ![]() In a word, CPP modification is a promising strategy for the PEEK implants to achieve osseointegration.ĭental implant surgery is a vital treatment for dentition defects and edentulism jaw. These findings indicated that CPP modification could significantly improve the biocompatibility and osteoinductive ability of PEEK-CPP implants in vitro. After CPP modification, the PEEK-CPP specimens had a porous and hydrophilic surface and presented enhanced cell adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. The surface characterization, layer degradation, biocompatibility and osteoinductive ability of the PEEK-CPP specimens were studied in vitro. In this study, the PEEK specimens were positively charged by 3-ammoniumpropyltriethoxysilane (APTES) modification, then the CPP was adsorbed onto the positively charged PEEK surface electrostatically to obtain CPP-modified PEEK (PEEK-CPP) specimens. Based on a lay-by-layer self-assembly technique, here we incorporated casein phosphopeptide (CPP) onto PEEK surface by a simple two-step strategy to address the poor osteoinductive ability of PEEK implants. However, its biological inertness and poor osteoinductive ability limited its clinical application. Polyetheretherketone (PEEK) is a potential implant material for dental application due to its excellent mechanical properties. ![]() 3Institute of Stomatology, Southwest Medical University, Luzhou, Sichuan, China.2Luzhou Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Luzhou, Sichuan, China.1The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, Sichuan, China. ![]()
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